pinna fetal alcohol syndrome

Gastric intubation of 1.5 g ethanol / kg body weight of mothers, a significant teratogenic response in ferrets (Mustela putorius) are treated once daily from gestational days 15 to 35 This response was evident by an increase in the incidence of fetuses with one or more abnormalities (21%), and by an increase in the frequency of litters with one or more malformed fetuses (50%). Palatoschisis and a greater relative inter-medial canthi distance in this study, the diagnostic features of fetal alcohol syndrome (FAS). Although the mean (± SEM) peak blood alcohol level sound of 207 ± 9 mg / dl has no effect on other reproductive parameters, high doses of alcohol (3.0 g / kg) resulted in the inability of the treated women to consume food or water, in the complete resorption of litters, and significant maternal mortality (88%). Fetal deaths occurred before Day 17 of pregnancy in the high alcohol dose group. On the basis of objective assessment of the differences between ethanol treated, pair-FED sucrosetreated, and untreated, ad libitum diet controls, the ferret seems to be a valuable alternative species for future studies on FAS. In addition, several animal studies have reported a maturational delay in pinna .